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Article: Caffeine-induced [Ca2+] oscillations in neurones of frog sympathetic ganglia.

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Cseresnyés Z; Bustamante AI; Schneider MF
J. Physiol. (Lond.), 1999


Table 1

Values of the model parameters used for the simulations presented in Fig. 4

Panel kSERCA(s−1) kRACT(s−1) KD(μM) kRyR,0(s−1) koff,PM(μM−1s−1) α
A 0.60 2.0 3.0 0.024 1.8 ± 10−4 0.6
B 0.25 3.5 4.0 0.012 3.6 ± 10−4 0.265
C 0.10 3.65 4.0 0.014 1.8 ± 10−4 0.4
D 0.60 2.0 3.0 0.015 n.a.* 0.6

  • ↵* In this simulation, the Ca2+-dependent inactivation of the leak coefficient of the RyR release channel was characterized by the following ‘on’ and ‘off’ rate constants: kon,RyR,1= 1.5 ± 10−3 s−1, koff,RyR,1= 10−4μM−1 s−1


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